Sildenafil is excreted as metabolites predominantly in the feces (about eighty% of administered oral dose) and to a lesser extent from the urine (about 13% of your administered oral dose). If taken using a significant-fat meal, absorption is minimized; the time taken to reach the utmost plasma focus increases by all around a person hour, and the maximum concentration by itself is lessened by almost one particular-3rd.[37] Route of administration
Avoid applying some other medicines to deal with impotence, such as alprostadil or yohimbine, devoid of very first speaking to your medical professional.
Sexual action may be a pressure on your own heart, especially if you have heart problems. In case you expertise chest agony, dizziness, or nausea through sexual action, contact your doctor straight away and keep away from sexual activity until your health care provider lets you know or else.
[48][forty nine] The Viagra name has grown to be so well-known, lots of bogus aphrodisiacs now connect with on their own "herbal viagra" or are presented as blue tablets imitating the shape and colour of Pfizer's product. Viagra can be informally known as "vitamin V", "the blue capsule", or "blue diamond", as well as a variety of other nicknames.
Sildenafil citrate one hundred mg commencing dose in Guys with erectile dysfunction in a global, double-blind, placebo-controlled research: effect on the sexual encounter and decreasing feelings of anxiety about the next intercourse endeavor.
an erection that won't go away (priapism). Should you have an erection that lasts greater than four hours, get health care help instantly.
Normally speak to your Health care service provider to ensure the information exhibited on this page applies to your personal circumstances.
-Clients should really look for quick clinical attention within the function of the unexpected loss of vision in one or equally eyes when having this drug.
Sildenafil is damaged down inside the liver by hepatic metabolism applying cytochrome p450 enzymes, mostly CYP450 3A4(major route), but in addition by CYP2C9 (minor route) hepatic isoenzymes. The key product of metabolisation by these enzymes is N-desmethylated sildenafil, that's metabolised additional. This metabolite also has an affinity for that PDE receptors, about 40% of that of sildenafil. As a result, the metabolite is responsible for about twenty% of sildenafil's motion.
Sildenafil may well result in other Unwanted side effects. Call your health practitioner In case you have any uncommon complications when you are using this medication.
Also, Gentlemen getting VIAGRA confirmed an advancement in their ability to get and preserve an erection compared to individuals who took placebo.
When you expertise a unexpected loss of eyesight when you are more info taking sildenafil, simply call your physician straight away. Usually do not take anymore doses of sildenafil or similar prescription drugs such as tadalafil (Cialis) or vardenafil (Levitra) until eventually you speak to your health practitioner.
Tentative proof suggests that sildenafil could enable men who expertise antidepressant-induced erectile dysfunction.[seven] Pulmonary hypertension
Retain this medication within the container it arrived in, tightly closed, and from arrive at of kids. Retail store the tablets at space temperature and clear of extra warmth and moisture (not in the toilet).